ZHOU Yu-jun, CHEN Qiu-yu, SUN Zhuo, TANG Jing-shu, LAN Jia-qi, WU Lei, PENG Ying. Advances of pathogenesis and drug development in amyotrophic lateral sclerosis[J]. Precision Medication Research, 2025, 1(2): 1-11.
Citation: ZHOU Yu-jun, CHEN Qiu-yu, SUN Zhuo, TANG Jing-shu, LAN Jia-qi, WU Lei, PENG Ying. Advances of pathogenesis and drug development in amyotrophic lateral sclerosis[J]. Precision Medication Research, 2025, 1(2): 1-11.

Advances of pathogenesis and drug development in amyotrophic lateral sclerosis

  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons. ALS patients develop progressive muscle atrophy, muscle weak and paralysis, finally died of respiratory failure. ALS is characterized by fast aggression and high mortality. What’s more, the disease is highly heterogeneous with unclear pathogenesis and lacks effective drugs for therapy. In this review, we summarize the main pathological mechanisms and the current drugs under development for ALS, which may provide a reference for the drug discovery in the future.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return